New England Journal of Medicine Publishes Research by UAMS Team on Myeloma Treatment Using Thalidomide -- Drug Increases Remission Rates in Clinical Trial
Little Rock, AR (ContentDesk) March 9, 2006 -- A long-term study on the effectiveness of the drug thalidomide as part of the treatment for multiple myeloma, one of the least curable cancers, showed improved remission rates in patients, reported a team of Myeloma Institute for Research and Therapy (http://myeloma.uams.edu) researchers led by Bart Barlogie, M.D., Ph.D., in the latest issue of the New England Journal of Medicine.The article Thalidomide and Hematopoietic-Cell Transplantation for Multiple Myeloma (http://content.nejm.org/cgi/content/full/354/10/1021?ijkey=NpKKiGnrNpOIE&keytype=ref&siteid=nejm) showed results from the addition of thalidomide to a myeloma treatment regimen that included high-dose, melphalan-based chemotherapy in a setting of tandem peripheral blood stem-cell transplants. In the trial, involving 668 myeloma patients between October 1998 and February 2004, those who received thalidomide as part of their treatment had a higher complete remission rate and a superior event-free, five-year survival rate (meaning there were no signs of relapse in that time period) than those in a control group. However, thalidomide failed to prolong overall survival and was associated with adverse side effects, including peripheral neuropathy -- damage to the peripheral nervous system -- and deep-vein thrombosis -- blood clots in the veins.The article appears in the March 9, 2006, issue of the weekly medical journal.Barlogie, lead researcher for the study, pioneered the use of thalidomide as a therapeutic agent in treating multiple myeloma. Thalidomide was tried initially in the case of unresponsive disease because of its anti-angiogenic properties -- meaning that it interferes with the blood supply to the tumor cells and thus kills through an indirect mechanism. Further research has shown that thalidomide exerts many potentially beneficial anti-tumor effects, Barlogie said, including direct tumor cell destruction and interruption of tumor-host cell interaction ( starve the seed by depleting the soil ).Lead UAMS researchers included:"???Barlogie, director of the Myeloma Institute for Research and Therapy (MIRT) (http://myeloma.uams.edu) at UAMS and a professor of medicine and pathology in the UAMS College of Medicine (http://www.uams.edu/com/)"???Guido Tricot, M.D., Ph.D., professor of medicine and pathology in the UAMS College of Medicine and director of clinical research for MIRT"???Elias Anaissie, M.D., professor of medicine in the UAMS College of Medicine and director of supportive care for MIRT "???John Shaughnessy, Ph.D.
professor of medicine in the UAMS College of Medicine, director of basic research for MIRT, and director of the Lambert Laboratory of Myeloma Genetics for MIRT"???Frits van Rhee, M.D., Ph.D., associate professor of medicine in the UAMS College of Medicine"???Maurizio Zangari M.D., associate professor of medicine in the UAMS College of MedicineOthers involved in the research included Erik Rasmussen, M.S., and John Crowley, Ph.D., of Cancer Research and Biostatistics at the University of Washington, Seattle. (http://www.washington.edu)Myeloma is a type of cancer that involves plasma cells white blood cells that produce antibodies. When plasma cells become cancerous, they reproduce uncontrollably and crowd out healthy red and white blood cells, preventing them from fighting infection and carrying oxygen throughout the body. Bone destruction is a common manifestation of myeloma. The malignant cells also produce a type of protein that can cause kidney failure.The average survival rate of a myeloma patient used to be three years upon diagnosis; thanks to research funded in part by the National Cancer Institute (NCI - http://www.cancer.gov), the MIRT (http://myeloma.uams.edu) has extended the average survival rate of its patients to seven years and beyond.The study was funded by a project program grant from the NCI, which in 2004 announced its third five-year renewal -- for nearly $18 million -- of grant support for the MIRT.
Those funds are earmarked for ongoing translational research at the MIRT, the first facility in the world created specifically to study and treat this rare form of cancer. About the University of Arkansas for Medical Sciences (UAMS):UAMS is the states only comprehensive academic health center, with five colleges, a graduate school, a medical center, five centers of excellence and a statewide network of regional centers. UAMS has about 2,320 students and 690 medical residents. It is one of the states largest public employers with almost 9,000 employees, including nearly 1,000 physicians who provide medical care to patients at UAMS, Arkansas Childrens Hospital and the VA Medical Center. UAMS and its affiliates have an economic impact in Arkansas of $4.3 billion a year.
UAMS centers of excellence are the Arkansas Cancer Research Center (http://www.acrc.uams.edu), Harvey and Bernice Jones Eye Institute (http://www.uams.edu/jei), Donald W. Reynolds Institute on Aging( http://centeronaging.uams.edu), Myeloma Institute for Research and Therapy (http://myeloma.uams.edu) and Jackson T. Stephens Spine & Neurosciences Institute (http://www.uams.edu/stephensinstitute).Contact:Andrea Peel, communications managerUAMS501-686-8996http://www.uams.edu | http://myeloma.uams.edu.
How Do Plasma Televisions Work?
Plasma TVs have been one of the most popular home entertainment solutions on the market for several years.
They offer outstanding resolution and a quality picture and are usually capable of displaying HDTV signals, allowing you to watch all of your favourite HDTV programs.
Compared to rear projection TVs, plasma technology offers some of the best viewing angles- no need to fight over the best seat anymore- and offer uniform screen brightness.
But how does plasma technology work?
It's pretty simple.
Some form of inert gas- say Xenon, for example, is inserted between two plates, which are held together, between which are over two million pixels, capable of producing a mind-boggling array of colors.
The gas is then energized by a charge which turns it into a viscous substance, creating an ultraviolet light, which allows each pixel to display the appropriate color.
Unlike rear-projection TVs, each pixel in a plasma display...
How Do Plasma Televisions Work?
Plasma > How Do Plasma Televisions Work?
Online Casino To Give Its Players Plasma TVs
(ContentDesk) September 9, 2005 -- Kiwi Casino, one of the most respected and trusted online casinos in the market, celebrates its 5th Birthday this October. To mark this special occasion Kiwi Casino will be giving away 42-inch Plasma TV's to three of its lucky players. "Plasma TV's are one of those 'must have' items that everyone would like to own. We felt they were a fitting gift to our players for their continuing loyalty and patronage during our first five years." commented James, a Kiwi Casino spokesperson. "Not only will these Plasma screens make watching TV a whole new experience but you can also attached computers to them.
This will allow our lucky winners to enjoy playing at Kiwi Casino in on over 6.5 square feet of widescreen TV, it will be like playing at a real life casino!"The competition is running from Sept.r 1st to Nov. 30th 2005. Every $??20 deposit into their Kiwi Casino account gets the player an entry into the Grand Prize Draw to be held in early December 2005....
Online Casino To Give Its Players Plasma TVs
Plasma > Online Casino To Give Its Players Plasma TVs
CRE Partners with Innovations Award Nominee at CES
Los Angeles, CA (ContentDesk) January 26, 2006 -- CRE Computer & AV Solutions works with Innovations Design and Engineering Award nominee, Empower Technologies, at the 2006 Consumer Electronics Show (CES), the largest technology event of the year.
This leading global-embedded technology company launched three award-nominated products at CES in Las Vegas this January, and they partnered with CRE Computer & AV Solutions to provide technology products and services for their product launch.CRE Computer & AV Solutions assisted Empower in creating an interactive demonstration of one of their new products.
CRE provided the necessary audiovisual rental equipment along with certified technicians for delivery and installation, and service and support.
By working with CRE Computer & AV Solutions at CES, we were able to have a great show and I look forward to using their expertise again said Damian Romanov, Empower Technologies Sales and Marketing Representative.CRE...
Plasma > CRE Partners with Innovations Award Nominee at CES
BCI Announces the First Fiber Optic RGB/Sync Video Transmission System Designed to Pass Tri-Level Sync for HDTV Video Specifications
Broadata Communications, Inc. (BCI), a world leader in the development of cutting edge optical communications and optoelectronic technologies announces that it has enhanced the ScreenLink? Fiber Optic Transport System.
This enhancement provides the unique ability to deliver High Definition (HD) video with tri-level synchronization, as well as Standard Definition (SD) video with bi-level synchronization.
Currently, there is no other product offering this tri-level sync feature.
The ScreenLink? now supports both the HD and SD specifications, as well as computer RGB video applications.
This additional functionality provides complete support for high-level graphics cards at all output resolutions.
This product development was motivated by the widespread adoption of HD video standards in the broadcast studio and digital signage marketplaces.
Although the ScreenLink? is designed for remote, multimedia video presentation applications, it...
Plasma > BCI Announces the First Fiber Optic RGB/Sync Video Transmission System Designed to Pass Tri-Level Sync for HDTV Video Specifications
CRE Partners with Innovations Award Nominee at CES
Los Angeles, CA (ContentDesk) January 26, 2006 -- CRE Computer & AV Solutions works with Innovations Design and Engineering Award nominee, Empower Technologies, at the 2006 Consumer Electronics Show (CES), the largest technology event of the year.
This leading global-embedded technology company launched three award-nominated products at CES in Las Vegas this January, and they partnered with CRE Computer & AV Solutions to provide technology products and services for their product launch.CRE Computer & AV Solutions assisted Empower in creating an interactive demonstration of one of their new products.
CRE provided the necessary audiovisual rental equipment along with certified technicians for delivery and installation, and service and support.
By working with CRE Computer & AV Solutions at CES, we were able to have a great show and I look forward to using their expertise again said Damian Romanov, Empower Technologies Sales and Marketing Representative.CRE...
Plasma > CRE Partners with Innovations Award Nominee at CES
Plasma
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